The GIST of it all: management of gastrointestinal stromal tumors (GIST) from the first steps to tailored therapy. A bibliometric analysis.

PURPOSE: Improvement of patient care is associated with increasing publication numbers in biomedical research. However, such increasing numbers of publications make it challenging for physicians and scientists to screen and process the literature of their respective fields. In this study, we present a comprehensive bibliometric analysis of the evolution of gastrointestinal stromal tumor (GIST) research, analyzing the current state of the field and identifying key open questions going beyond the recent advantages for future studies to assess. METHODS: Using the Web of Science Core Collection, 5040 GIST-associated publications in the years 1984-2022 were identified and analyzed regarding key bibliometric variables using the Bibliometrix R package and VOSviewer software. RESULTS: GIST-associated publication numbers substantially increased over time, accentuated from year 2000 onwards, and being characterized by multinational collaborations. The main topic clusters comprise surgical management, tyrosine kinase inhibitor (TKI) development/treatment, diagnostic workup, and molecular pathophysiology. Within all main topic clusters, a significant progress is reflected by the literature over the years. This progress ranges from conventional open surgical techniques over minimally invasive, including robotic and endoscopic, resection techniques to increasing identification of specific functional genetic aberrations sensitizing for newly developed TKIs being extensively investigated in clinical studies and implemented in GIST treatment guidelines. However, especially in locally advanced, recurrent, and metastatic disease stages, surgery-related questions and certain specific questions concerning (further-line) TKI treatment resistance were infrequently addressed. CONCLUSION: Increasing GIST-related publication numbers reflect a continuous progress in the major topic clusters of the GIST research field. Especially in advanced disease stages, questions related to the interplay between surgical approaches and TKI treatment sensitivity should be addressed in future studies.

Bibliometric analysis of horticultural crop secondary metabolism.

The goal of the study was to examine the trends in recent years by analyzing 750 studies, 3619 authors, and 166 sources with the statement "Horticultural Crop Secondary Metabolism" in the article title published within the scope of SCI-Expanded and "Scopus" journals in between the years 2010 and 2023. In this case, the Web of Science Core Collection database was scanned under the heading "Horticultural Crop Secondary Metabolism", and bibliometric information was gathered. In order to advance research on horticulture crops, current problems and recommend solutions within "Horticultural Crop Secondary Metabolism" were identified in this study. The number of publications, publication kinds, reference analyses, total citations per year, most common words, most often cited local authors, most pertinent affiliations, and most pertinent sources were all examined in relation to the research. According to the findings, Horticulture Research, Frontiers in Plant Science, Plant Physiology and Biochemistry: PPB, Scientific Reports, and BMC Genomics are the journals that publish the most papers on "Horticultural Crop Secondary Metabolism". The phrases "gene expression regulation plant", "transcriptome", and "plant proteins" are used most frequently. Because of this, the increase of bibliometrics study can be very beneficial by serving as a catalyst for horticulture crop research.

A visualization analysis of hotspots and global trends on pelvic floor dysfunction in cervical cancer.

BACKGROUND/OBJECTIVE: Cervical cancer is the major cause of cancer-related mortalities in women globally. It constitutes one of the life-threatening conditions for women in developing countries. The popularization of cervical cancer screening and the improvement of treatment levels has caused the mortality rate of cervical cancer to decrease gradually, but pelvic floor dysfunction before and after cervical cancer treatment has become prominent and attracted more and more attention. Bibliometric analysis has been carried out in this research. The main goal of this research is to provide a comprehensive insight into the knowledge structure and global research hotspots about pelvic floor dysfunction in cervical cancer. METHODS: Literature related to cervical cancer and pelvic floor dysfunction as of May 2023 was searched on the Web of Science Core Collection (WOSCC). The visualization and bibliometric analyses of the number and contents of publications were performed to analyze the temporal trends, spatial distribution, collaborative networks, influential references, keyword co-occurrence, and clustering. RESULTS: There were 870 publications from 74 countries or regions, with the U.S. publications in a leading position. Since 2020, the number of publications has rapidly increased with the emphasis on the quality of life of cervical cancer patients. Although pelvic floor dysfunction in cervical cancer mainly occurs in developing countries, developed countries have made great contributions to this disease. However, in developing countries such as China and India, the quality of publications needs to be improved. In this field, the studies focused on the sexual dysfunction or urinary incontinence of cervical cancer patients, and the most cited papers discussed the effect of cervical cancer treatment on the sexual activities of females. The frontier keywords were represented by pelvic radiotherapy and risk factors. CONCLUSION: This study provides an objective and comprehensive analysis of the literature available on pelvic floor dysfunction in cervical cancer and identifies future trends and current hotspots. It can provide a valuable reference for researchers in this field.

The pediatric anesthesiology publication activity and landscape over the past two decades: A longitudinal scientometric analysis.

BACKGROUND: Scientometric analyses characterize the output of research publications using quantitative methods. While it has been reported that the number of publications in anesthesiology has been increasing for years, the global research activity in pediatric anesthesiology and its landscape is largely unknown. AIMS: To examine the activity, developmental dynamics, and collaboration landscape of research publications in pediatric anesthesiology over the past two decades. METHODS: PubMed and WebOfScience were searched for pediatric anesthesiology publications published between 2001 and 2020. The identified publications were exported into a database, matched, curated, and then assigned to one or more countries according to their affiliation field(s). The primary outcome was the publication activity and its growth rate. Secondary outcomes included the geographical distribution, the evolution of international collaborations (as indicated by articles affiliated with more than one country), and the main sources. RESULTS: Thirty-four thousand, three hundred and forty-three pediatric anesthesiology publications were retrieved. The compound annual growth rate over the study period was +7.6%. The highest annual growth rate was +20.6% from 2019 to 2020. Corresponding authors were most often affiliated with USA (32.5%), Germany (5.5%), and China (5.5%). China (+22.9%), Iran (+21.7%), and India (+16.1%) had the highest compound annual growth rates. 6001 (17.5%) articles involved international collaboration, with a compound annual growth rate of +13.1%. The most frequent collaboration was between USA and Canada (716 articles together). The most prominent source was Pediatric Anesthesia (10.0%). CONCLUSIONS: Publication activity in pediatric anesthesiology has increased from 2001 to 2020 and has become more geographically diverse. With the volume of international collaborations even outpacing this growth, it is hoped that this will gradually lead to a larger evidence base in pediatric anesthesia.

Orthopaedic surgery academic productivity - how do we measure up?

PURPOSE: Research is vital for evidence-based surgery. Understanding scientometric differences among surgical specialties has scope to inform discussions within and across surgical specialities to develop and maintain a culture of research productivity. This study aims to quantify Australian orthopaedic surgical academic productivity compared to the other specialties within the Royal Australasian College of Surgeons' (RACS). METHODS: A list of Australian surgeons registered with RACS was compiled using the "find a surgeon" function on the RACS Web site. This list was cross-referenced with the specialty databases on their respective websites. A name search of the SCOPUS database for each individual surgeon was performed. For each individual h-index, m-index, total active publishing years, total publications, and total citations were collected. RESULTS: Orthopaedic surgeons had the equal lowest h-index median 2 (interquartile range:3), the shortest duration involved in research median 5 years (14), produced the fewest articles median 2 (7) and attained the second lowest number of citations median 28 (116) of the Australian surgical specialties. When the 10 individuals with highest h-index are compared among specialties, orthopaedic surgeons rank second with a median of 37 (6.5). CONCLUSION: Our objective data provides a factual comparison and baseline assessment of one aspect of research productivity. It can challenge currently held perceptions of performance and can inform conversations about strategic development. We recommend this assessment to other international Colleges and Societies on regular basis. These accurate academic productivity metrics provide opportunity for developing and maintaining a culture of sustained, significant contribution to surgical research.

Trends of Publications on Single- and Double-Bundle ACL Reconstructions over the Last 20 Years: A Bibliometric Analysis of the PubMed Literature.

Purpose: To improve the clinical outcomes of anterior cruciate ligament reconstruction (ACLR), there have been attempts to reproduce anatomic reconstruction by modifying the single-bundle (SB) and double-bundle (DB) techniques. Although DB ACLR restores better rotational control compared to SB ACLR, it is still debatable whether there are higher clinical outcomes in favor of DB ACLR. We aimed to study the trends of publications on SB and DB ACLR techniques over the last 20 years. Methods: For this bibliometric study, we performed a PubMed search on 31/05/2022 with a well-defined search strategy. The articles were downloaded into Excel software, and citations were determined from the iCite website for PubMed. The analysis was performed using SPSS software version 28.0.1. Data mining was performed using Orange software, Mac version 3.32.0, from the titles of all articles and each group of SB and DB ACLR. The output is presented as word clouds. Results: A total of 10,530 publications were identified, of which 9699 publications (92.1%) pertained to SB-ACLR and 831 publications (7.9%) to DB-ACLR. There was a steady increase in the publications on SB-ACLR until 2012, followed by a steep increase that peaked in 2021. The highest number of publications on DB-ACLR was in 2012 (n = 76; 9.1%). The mean citations per year for SB-ACLR and DB-ACLR were 2.87 ± 4.31 and 2.74 ± 3.17, respectively. The most prolific journals publishing on this topic were Knee Surgery Sports Traumatology Arthroscopy, American Journal of Sports Medicine, and Arthroscopy. The top three articles that received the maximum number of citations were from Japanese authors. Conclusion: The number of publications related to SB-ACLR was significantly higher than that related to DB-ACLR in the last 20 years. The publications related to DB-ACLR have decreased in the recent past, after reaching a peak in 2012. The citations per year of SB-ACLR and DB-ACLR were similar.

Comprometimento Organizacional: revisões de literatura de 2009 a 2019 / Organizational Commitment: literature reviews from 2009 to 2019

O Comprometimento Organizacional (CO) é um vínculo do indivíduo com a organização, sendo os três componentes mais aceitos desse estado psicológico o afetivo, instrumental e normativo. O construto foi introduzido na literatura há algumas décadas e interessa gestores e acadêmicos, porque está associada a resultados organizacionais desejáveis. Entretanto, apesar da longevidade, ainda existem questões na compreensão do fenômeno e faz-se necessário identificar as lacunas de pesquisa. Assim, o objetivo deste trabalho foi realizar revisão sistemática de literatura das revisões sistemáticas de literatura, metanálises e bibliometrias publicadas em português e inglês, entre 2009 e 2019, no portal de periódicos da Capes, em português e inglês. Foram identificados 15 trabalhos, nos quais foi possível verificar a prevalência das investigações de antecedentes em detrimento dos consequentes, havendo correspondência e congruências entre os achados dos preditores. Os autores dos estudos selecionados apontam limitações na concepção dos elementos constituintes do construto e sua dimensionalidade, o que reflete na medida. Os achados desta revisão indicam que o campo do CO se encontra em um estágio consolidado. Contudo, anseia por novas investigações que respondam aos questionamentos ainda existentes e auxiliem na execução de intervenções práticas nos mais diversos contextos organizacionais.

Organizational Commitment (OC) is an attachment of the individual of the organization, and the three most accepted components of this psychological state are affective, instrumental, and normative. The construct was introduced into the literature a few decades ago and interests managers and academics, for its association with desirable organizational outcomes. However, despite its longevity, there are still issues in understanding the phenomenon, for identifying research gaps. Thus, the aim of this work was to conduct a systematic literature review of systematic literature reviews, meta-analyses, and bibliometrics published in Portuguese and English, between 2009 and 2019, on the Capes journal portal. Fifteen studies were identified, in which it was possible to verify the prevalence of investigations of antecedents over consequents, with correspondence and congruences between the findings of the predictors. The authors of the selected studies point out limitations in the design of the construct's constituent elements and its dimensionality, which reflects on the measurement. The findings of this review indicate that the field of OC is at a consolidated stage. However, it looks forward to further research that answers the questions that still exist and assists in the execution of practical interventions in the most different organizational contexts.

The Role of Ultrasound in Cancer and Cancer-Related Pain-A Bibliometric Analysis and Future Perspectives.

Ultrasound has a deep penetrating ability with minimal or no tissue injury, while cancer-mediated complications during diagnosis, therapy, and surgery have become a serious challenge for clinicians and lead to the severity of the primary condition (cancer). The current study highlights the importance of ultrasound imaging and focused ultrasound therapy during cancer diagnosis, pain reduction, guidance for surgical resection of cancer, and the effectiveness of chemotherapy. We performed the bibliometric analysis on research domains involving ultrasound, cancer management, pain, and other challenges (chemotherapy, surgical guidance, and postoperative care), to observe the trend by which the research field has grown over the years and propose a possible future trend. The data was obtained from the Web of Science, processed, and exported as plain text files for analysis in the Bibliometrix R web interface using the Biblioshiny package. A total of 3248 documents were identified from 1100 journal sources. A total of 390 articles were published in 2022, with almost a 100% growth rate from previous years. Based on the various network analysis, we conclude that the outcome of the constant research in this domain will result in better patient care during the management of various diseases, including cancer and other co-morbidities.

Research Hotspots in Psoriasis: A Bibliometric Study of the Top 100 Most Cited Articles.

(1) Introduction: Psoriasis is a chronic, immune-mediated disease that negatively impacts patients' quality of life and predisposes them to cardiovascular or metabolic diseases. This paper aims to summarize the knowledge structure and future directions in psoriasis research by means of bibliometrics. (2) Material and methods: The Thomson Reuters Web of Science database was interrogated using preestablished keywords. A list of the top 100 most cited articles focusing solely on psoriasis was compiled and analyzed. VOSviewer software was used to assess and visualize collaboration networks, citation, co-citation and co-wording analysis, and bibliographic coupling. (3) Results: The articles were written by 902 authors from 20 countries and were published in 31 journals. The United States was at the forefront of this field. Griffiths, CEM had the most citations, while the most prolific institution was Rockefeller University, New York City. Pathogenesis, especially key-pathogenic factors, immune pathways, and epidemiology were the most discussed topics. Work published in the last decade focused on the use of biologics. Keywords such as "quality of life", "efficacy", and "necrosis-factor alpha" have been widely used. (4) Conclusion: Research interest regarding psoriasis is high, leading to the rapid development of this field. Treatment modalities, especially novel-targeted therapies, immune pathways, and an integrative approach to such cases are receiving great interest and represent research hotspots in the future.

Global Research Trend on Allergic Skin Disorders: A Bibliometric Analysis from 2001 to 2020.

Background: Allergic skin disorders constitute a variety of inflammatory skin disorders with increasing incidence. Bibliometric studies involve a statistical analysis of academic literature to assess the current research trend and identify knowledge gaps. There is a dearth of such studies concerning allergic skin disorders. Aim: To perform a bibliometric analysis of global research concerning allergic skin disorders from 2001 to 2020. Materials and Methods: We obtained all data from the Web of Science using the keywords "atopic dermatitis," "contact dermatitis," "skin allergy," "urticaria," "food allergy," and "drug allergy." Only articles in English language were included. Subsequent analysis revealed the total number of publications, top journals, institutions, and countries, thus highlighting the overall research trend. Results: Overall 76,764 articles were published on allergic skin disorders from 2001 to 2020 (original articles > review articles). The United States of America (USA) contributed maximum publications (26.1%) followed by Germany (9.6%), Japan (8.2%), and England (8.1%). The Allergy is the most preferred journal for publishing skin allergy research. Most research concentrated on atopic dermatitis, pathomechanisms of allergic disorders, and their primary prevention. Conclusion: This study evaluates the current landscape of skin allergy research. There has been a consistent increase in the number of publications concerning allergic skin disorders over the years. However, majority of the research publications are from developed countries. Hence, skin allergy-related research publication should be increased for diverse and enriched literary evidences.

A century of retroperitoneal soft-tissue sarcoma research: From single center experience to precision oncology? A bibliometric analysis of past, present, and future perspectives.

BACKGROUND: Increasing publication numbers in the biomedical field led to an improvement of patient care in many aspects but are challenging for scientists when integratively processing data of their fields. Using bibliometric analyses, the present study assesses the productivity and predominant topics in retroperitoneal soft-tissue sarcoma (RPS) research across the past 122 years, thereby identifying crucial questions to address in future RPS research. METHODS: Using the Web of Science Core Collection, 1018 RPS-associated publications from 1900 to 2022 were identified and analyzed regarding key bibliometric variables using the Bibliometrix R package and the VOSviewer software. RESULTS: A continuous increase in RPS-associated publication numbers can be noticed over the time, which is strongly pronounced from 2005 onwards, and is characterized by a multinationally driven collaborative clinical research focus. The research primarily reflects progression regarding surgical techniques, histology-based therapy, radiotherapy regimens, and identification of prognostic clinicopathological factors. This progression is accompanied with improved overall survival of RPS patients. However, a paucity of RPS-specific basic/translational research indicates that such research might be additionally needed to better understand the pathophysiology of RPS and with that to enable the development of personalized therapies and to further improve patient outcome. CONCLUSION: Increasing publication numbers of multinationally driven clinical RPS research are accompanied with improved overall survival of RPS patients, highlighting the importance of international collaborations to facilitate future clinical trials. However, this bibliometric analysis reveals a lack of RPS-specific basic/translational research which is needed to further improve patient outcome in the context of precision oncology.

Essential oil encapsulation by electrospinning and electrospraying using food proteins: A review.

Proteins are excellent polymeric materials for encapsulating essential oils (EOs) by electrospinning and electrospraying to protect these compounds and form nanomaterials with active properties. Proteins can encapsulate bioactive molecules by several mechanisms, including surface activity, absorption and stabilization mechanisms, amphiphilic nature, film-forming capacity, foaming, emulsification, and gelation, due to interactions among their functional groups. However, proteins have some limitations in encapsulating EOs by the electrohydrodynamic process. Their properties can be improved by using auxiliary polymers, increasing their charges by adding ionic salts or polyelectrolytes, denaturing their structure by heat, and exposure to specific pH conditions and ionic strength. This review addresses the main proteins used in electrospinning/electrospraying techniques, production methods, their interactions with EOs, bioactive properties, and applications in food matrices. Multivariate analysis associated with bibliometrics of metadata extracted from studies in Web of Science using the keywords electrospinning and essential oil (EO) were used as the search strategy.

Pharmacological treatment and vaccines in monkeypox virus: a narrative review and bibliometric analysis.

Mpox (earlier known as monkeypox) virus infection is a recognized public health emergency. There has been little research on the treatment options. This article reviews the specific drugs used to treat mpox virus infection and the vaccines used here. Instead of focusing on the mechanistic basis, this review narrates the practical, real-life experiences of individual patients of mpox virus disease being administered these medicines. We conducted a bibliometric analysis on the treatment of the mpox virus using data from several databases like PubMed, Scopus, and Embase. The research on this topic has grown tremendously recently but it is highly concentrated in a few countries. Cidofovir is the most studied drug. This is because it is indicated and also used off-label for several conditions. The drugs used for mpox virus infection include tecovirimat, cidofovir, brincidofovir, vaccinia immune globulin, and trifluridine. Tecovirimat is used most frequently. It is a promising option in progressive mpox disease in terms of both efficacy and safety. Brincidofovir has been associated with treatment discontinuation due to elevated hepatic enzymes. Cidofovir is also not the preferred drug, often used because of the unavailability of tecovirimat. Trifluridine is used topically as an add-on agent along with tecovirimat for ocular manifestations of mpox virus disease. No study reports individual patient data for vaccinia immune globulin. Though no vaccine is currently approved for mpox virus infection, ACAM 2000 and JYNNEOS are the vaccines being mainly considered. ACAM 2000 is capable of replicating and may cause severe adverse reactions. It is used when JYNNEOS is contraindicated. Several drugs and vaccines are under development and have been discussed alongside pragmatic aspects of mpox virus treatment and prevention. Further studies can provide more insight into the safety and efficacy of Tecovirimat in actively progressing mpox virus disease.

Bibliometric spotlight on thoracic surgery specialization theses in Turkey.

Introduction: Scientific publications originating from medical specialty theses are seen as a start to an academic career for clinicians and a criterion to work in academia in Turkey. Aim: To evaluate thoracic surgery theses in the period 2001-2019 in publication and other bibliometric parameters. Material and methods: Our study investigated 319 theses prepared in the thoracic surgery field between January 2001 and December 2019 and registered in the National Thesis Center. We identified and recorded the author's gender, institution, research method, publication status, time, citations, journals' index, and author's order using Google Scholar, Web of Science Basic Search, and Master Journal List. Results: Of the 319 evaluated, 262 theses were from universities, and 57 were in Training and Research Hospitals. Thirty-two studies (10%) were experimental or prospective clinical. The number of published studies (38.5%) in journals was 123 (66 SCI/SCI-E, 8 ESCI, three other international indexes, and 46 national indexes). Sixty (18.8%) authors were women. The mean time to publication was 4.31 ±2.95 years. It was 3.3 years for female researchers (p = 0.029). Experimental/prospective studies in universities were relatively higher. The number of citations in SCI/SCI-E journals was significantly higher (p < 0.001). The time to the publication of experimental/prospective studies was shorter (p = 0.039). Conclusions: The publication rate of thoracic surgery theses was 38.5%. Female researchers published their studies earlier. Articles in SCI/SCI-E journals had a higher number of citations. The time to publication was significantly shorter in experimental/prospective studies. This study is the first in the literature as a bibliometric report of the thoracic surgery thesis.

Cyclic vomiting syndrome, a common language? A 20-year bibliometric study.

BACKGROUND: Cyclic vomiting syndrome (CVS) is recognized as an episodic syndrome associated with migraine in the last version of the International Classification of Headache Disorders (ICHD-3). It manifests as stereotypical episodes of intense nausea and vomiting, occurring preferentially in childhood. Over the last 2 decades, the knowledge of this disorder has increased. The diagnostic criteria have been modified, through the evolution of several successive classifications. Actually, two classifications are prominent in the literature: the ICHD-3 and the Rome IV classification. The predictable periodicity of episodes is only recognized in the ICHD-3. OBJECTIVE: We aimed to analyze the evolution of CVS literature in the last 2 decades, with a focus on CVS criteria used in these papers. METHODS: We conducted a bibliometric study. We searched in the Web of Science database all papers in English literature with the term CVS in the abstract or title, in the category "article" or "review", published from 2001 to 2020. We searched within the paper which classification was used or mentioned. RESULTS: In total, 213 papers were analyzed. 116 papers exclusively concerned childhood and adolescence CVS, or were written by pediatric practitioners. For most of the papers, the corresponding author was specialized in the field of gastroenterology. The Rome III classification was the main classification used or mentioned. The ICHD-3 and its beta version were mostly used or mentioned by the authors affiliated to the neurologic field. CONCLUSION: This study shows the growth in the number of publications on CVS. It highlights the lack of reference to the ICHD, in particular by practitioners in the field of gastroduodenal disorders. This should encourage the achievement of a common classification with the different scientific societies.

Research Trends of Vitamin D Metabolism Gene Polymorphisms Based on a Bibliometric Investigation.

Vitamin D requires activation to show its pharmacological effect. While most studies investigate the association between vitamin D and disease, only a few focus on the impact of vitamin D metabolism gene polymorphisms (vitDMGPs). This bibliometric study aims to provide an overview of current publications on vitDMGPs (CYP27B1, CYP24A1, CYP2R1, CYP27A1, CYP2R1, DHCR7/NADSYN1), compare them across countries, affiliations, and journals, and inspect keywords, co-citations, and citation bursts to identify trends in this research field. CiteSpace© (version 6.1.R3, Chaomei Chen), Bibliometrix© (R version 4.1.3 library, K-Synth Srl, University of Naples Federico II, Naples, Italy), VOSviewer© (version 1.6.1, Nees Jan van Eck and Ludo Waltman, Leiden University, Leiden, Netherlands) and Microsoft® Excel 365 (Microsoft, Redmond, Washington, USA) classified and summarized Web of Science articles from 1998 to November 2022. We analyzed 2496 articles and built a timeline of co-citations and a bibliometric keywords co-occurrence map. The annual growth rate of vitDMGPs publications was 18.68%, and their relative research interest and published papers were increasing. The United States of America leads vitDMGPs research. The University of California System attained the highest quality of vitDMGPs research, followed by the American National Institutes of Health and Harvard University. The three productive journals on vitDMGPs papers are J. Steroid. Biochem. Mol. Biol., PLOS ONE, and J. Clin. Endocrinol. Metab. We highlighted that the vitDMGPs domain is relatively new, and many novel research opportunities are available, especially those related to studying single nucleotide polymorphisms or markers in a specific gene in the vitamin D metabolism cycle and their association with disease. Genome-wide association studies, genetic variants of vitDMGPs, and vitamin D and its role in cancer risk were the most popular studies. CYP24A1 and CYB27A1 were the most-studied genes in vitDMGPs. Insulin was the longest-trending studied hormone associated with vitDMGPs. Trending topics in this field relate to bile acid metabolism, transcriptome and gene expression, biomarkers, single nucleotide polymorphism, and fibroblast growth factor 23. We also expect an increase in original research papers investigating the association between vitDMGPs and coronavirus disease 2019, hypercalcemia, Smith-Lemli-Opitz syndrome, 27-hydroxycholesterol, and mendelian randomization. These findings will provide the foundations for innovations in the diagnosis and treatment of a vast spectrum of conditions.

Advances in studies on the plant rhizosphere microorganisms in wetlands: A visualization analysis based on CiteSpace.

Rhizosphere microorganisms and their interactions with plants in wetlands have recently attracted much attention due to their importance in enhancing plant environmental adaptation, removing wetland pollutants, and alleviating climate change. However, the fluctuating hydrological environment of wetlands leads to more complex dynamics in the rhizosphere environment. Research progress and hotspots concerning plant-rhizosphere microorganisms under special wetland environments are still kept unclear. To better understand the current research status, hotspots and trends of rhizosphere microorganisms in wetlands, we used CiteSpace bibliometric software to visualize and analyze 231 English-language publications from the Web of Science core collection database. Here, we reviewed the role played by various countries, institutions, and scholars in the studies of plant rhizosphere microorganisms in wetlands based on cooperation network analysis. We discussed the shift from bioremediation and nutrient removal to rhizosphere microbial community composition as a research hotspot for plant rhizosphere microorganisms in wetlands according to keyword co-occurrence and clustering analysis. Finally, we highlighted that more attention should be paid to the ecological functions of rhizosphere microorganisms in different wetland ecosystems, and the plant‒microbe microinterface processes and interaction patterns should be explored in depth to provide new indicators for the evaluation of wetland ecosystem functions.

Global review and state-of-the-art of biomass and carbon stock in the Amazon.

Understanding how studies have been carried out in the region helps to understand the Amazon rainforest potential in mitigating climate change. In addition, evaluating scientific production is essential to verify the main methods and places researched. Thus, this study objective was to build an overview and identify the main gaps regarding research related to biomass and carbon stocks with the coverage limit of the Amazon rainforest. Therefore, an analysis of the publications indexed in the Scopus database was developed until 2020, performing a bibliometric analysis and a systematic and state-of-the-art review. Initially 2042 publications were obtained, of which 786 met the inclusion criteria. The first work indexed in the Scopus database related to the theme was published in 1982. Over time, it was possible to observe an increasing behavior in relation to the interest in the theme. Natural environments were the most researched and change in the land use and occupation of the Amazon Rainforest is still poorly evaluated. Brazil is the country with the highest number of studies, followed by Peru and Colombia. Guyana and Suriname appear as possible scientific gaps and potential environments to be studied. Studies preferentially explore the biomass carbon, with the soil being little evaluated when compared to the total amount of papers found. When observing only the biomass studies, the aboveground biomass is the most evaluated, while the roots and necromass are little studied. The main variables used in biomass equations were diameter at 1.3 m above ground and total tree height. The biomass to carbon conversion factor has been widely used, but it can generate unreliable results. It is recommended to carry out local assessments of the carbon content, especially using the dry combustion method, which generates less waste, with more precise results and shorter execution time of the analyses. Such assessments present values for the location that can avoid false or misinterpretations of the biomass and carbon stocks in the Amazon Rainforest.

Transtornos de ansiedade em idosos: um estudo bibliométrico anxiety disorders in the elderly people: a bibliometric study / Anxiety disorders in the elderly: a bibliometric study anxiety disorders in the elderly people / Trastornos de ansiedad en ancianos: estudio bibliométrico trastornos de ansiedad en ancianos

OBJETIVO: Esboçar o panorama científico sobre os sintomas dos transtornos de ansiedade em idosos. MÉTODOS: Trata-se de um artigo original com abordagem descritiva através de um estudo bibliométrico a partir de dois bancos gerados pela SCOPUS, os dados foram organizados com o Rayyan com a retirada das duplicidades e o VOSviewer foi o software escolhido para realizar as análises bibliométricas. RESULTADOS: Destaca-se que as análises bibliométricas agruparam os termos em clusters, corroborando com os pressupostos teóricos encontrados, com a prevalência de sintomas clínicos e doenças neurológicas associando-se com as intervenções e aspectos sociais, entretanto, os índices também revelam novas linhas de pesquisas. A partir das análises mais minuciosas e individualizadas da bibliometria, podemos inferir que os termos associados aos sintomas dos transtornos de ansiedade e idosos estabelecem baixa correlação, existindo assim, lacunas e fragilidades no campo de pesquisa com este tema. CONCLUSÃO: Este estudo permitiu explorar os sintomas dos transtornos de ansiedade em idosos através do campo literário e científico produzido em 2020, 2021 e 2022 em um cenário mundial com o total de 22.087 documentos, sendo 17.665 artigos e 4.422 revisões. Sugerimos que novos estudos com o objetivo de avançar frente a temática, ressaltando a importância dos estudos longitudinais e/ou multidisciplinares devido à natureza das variáveis.

Outline the scientific panorama on the symptoms of anxiety disorders in older adults. METHODS: It is an original article with a descriptive approach through a bibliometric study from two databases generated by SCOPUS, the data were organized with Rayyan with the removal of duplicates and VOSviewer was the software chosen to perform the bibliometric analyzes. RESULTS: It is noted that bibliometric analyzes grouped the terms into clusters, corroborating the theoretical assumptions found, with the prevalence of clinical symptoms and neurological diseases associating with interventions and social aspects, however, the indices also reveal new lines of research. From the most detailed and individualized analyzes of bibliometry, we can infer that the terms associated with the symptoms of anxiety disorders and the elderly establish low correlation, thus existing gaps and weaknesses in the field of research with this theme. CONCLUSION: This study allowed to explore the symptoms of anxiety disorders in older adults through the literary and scientific field produced in 2020, 2021 and 2022 in a global setting with a total of 22,087 documents, 17,665 articles and 4,422 reviews. We suggest that new studies with the aim of advancing the subject, emphasizing the importance of longitudinal and/or multidisciplinary studies due to the nature of the variables.

Esbozar el panorama científico sobre los síntomas de los trastornos de ansiedad en los adultos mayores. MÉTODOS: Es un artículo original con enfoque descriptivo a través de un estudio bibliométrico a partir de dos bases de datos generadas por SCOPUS, los datos fueron organizados con Rayyan con la eliminación de duplicados y VOSviewer fue el software elegido para realizar los análisis bibliométricos. RESULTADOS: Se observa que los análisis bibliométricos agruparon los términos en conglomerados, corroborando los supuestos teóricos encontrados, con la prevalencia de síntomas clínicos y enfermedades neurológicas asociadas a intervenciones y aspectos sociales, sin embargo, los índices también revelan nuevas líneas de investigación. A partir de los análisis más detallados e individualizados de la bibliometría, podemos inferir que los términos asociados a los síntomas de los trastornos de ansiedad y los adultos mayores establecen baja correlación, existiendo así brechas y debilidades en el campo de la investigación con este tema. CONCLUSIÓN: Este estudio permitió explorar los síntomas de los trastornos de ansiedad en adultos mayores a través del campo literario y científico producido en 2020, 2021 y 2022 en un escenario global con un total de 22.087 documentos, 17.665 artículos y 4.422 revisiones. Se sugiere realizar nuevos estudios con el objetivo de avanzar en el tema, enfatizando la importancia de los estudios longitudinales y/o multidisciplinares debido a la naturaleza de las variables.